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KMID : 0381120170390020237
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Genes and Genomics
2017 Volume.39 No. 2 p.237 ~ p.242
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Novel phenotypes of Drosophila spinster locus on the head formation during embryogenesis
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Kim Ji-Sun
Park Ki-Seok
Park Ok-Kyu
Kim Sang-Hee
Jeon Sang-Hak
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Abstract
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spinster (spin) is a late endosome/lysosome membrane protein with the amino acid sequence of a lysosomal sugar carrier and expressed in the glial cells. Spin is required for autophagy and lysosome reformation by releasing lysosomal degradation products of autolysosome into the cytosol in Drosophila larvae and adults. However, such kind of function has not been investigated in embryos yet. In this study, for the first time, we examined the effects of spin mutation on the endocytic pathway and autophagy during embryogenesis. Loss-of-function spin mutation led to the abnormal process of early endosome/recycling endosome and the accumulation of enlarged autophagosome/autolysosome. These abnormal endocytic pathway and autophagy subsequently caused the malformation of head at embryonic stages. These results show that Spin is involved in the endocytic pathway and autophagy during embryogenesis as well as larval and adult stages.
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KEYWORD
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Spinster, Drosophila, Autophagy, Head formation
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